Cyclopropylacetylene

Cyclopropylacetylene

CAS number:6746-94-7
Abbreviation: CPA
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Description

Zhejiang Realsun Chemical Co., Ltd. is one of the most reliable manufacturers and suppliers of cyclopropylacetylene in China. If you're going to buy high quality cyclopropylacetylene, welcome to get pricelist and free sample from our factory. Good service and low price are available.

 

  • Chinese alias: Cyclopropaneacetylene

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Cyclopropylacetylene (CPA) is a specialty chemical building block containing both a highly reactive alkyne group and a rigid cyclopropyl structure.
This combination makes CPA a valuable intermediate for selected pharmaceutical, agrochemical and advanced materials synthesis routes where conventional chemical raw materials cannot readily provide the same molecular structure.
Liansheng currently supplies industrial-grade Cyclopropylacetylene with a purity of ≥99.5% for commercial applications.

 

Key Product Information

 

Item

Specification

Product Name

Cyclopropylacetylene

Common Name

Cyclopropylacetylene

Abbreviation

CPA

CAS No.

6746-94-7

Molecular Formula

C₅H₆

Appearance

Colorless, free-flowing liquid

Commercial Grade

Industrial Grade

Assay Purity

≥99.5%

CPA is primarily positioned as a specialty building block for pharmaceutical and agrochemical synthesis, with additional applications in selected advanced-material development projects.

 

Technical Specifications

 

Each commercial batch is subject to quality inspection and can be supplied with a batch-specific COA.

Test Item

Industrial Grade Specification

Assay Purity

≥99.5%

Water Content

≤200 ppm

Density at 25°C

0.780–0.782 g/cm³

Boiling Point at Atmospheric Pressure

51°C

Free Amine Residue

≤100 ppm

For customers with additional impurity limits or application-specific analytical requirements, the target specification can be reviewed before commercial qualification.

 

Cyclopropyl acetylene - Uses and Synthesis Methods Overview

 

Cyclopropyl acetylene is a key intermediate for the anti-AIDS specific drug Efavirenz. Efavirenz is a non-nucleoside reverse transcriptase inhibitor that can be used in highly active antiretroviral therapy to treat HIV Type I, a Class A human immunodeficiency virus. It is a colorless and transparent liquid with a boiling point of 52-53°C (according to Chemicalbook), a refractive index (D420) of 1.4280, and a density of 0.7786.

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Applications

 

1. Pharmaceutical Intermediate Manufacturing
Cyclopropylacetylene is used as a specialty building block in the synthesis of selected pharmaceutical intermediates, including routes associated with antiviral, anticancer and respiratory antiviral compounds.
Its cyclopropyl-alkyne structure can be incorporated into downstream synthesis routes and may help simplify certain synthetic sequences.
Application Considerations
Raw material impurity levels can affect downstream pharmaceutical synthesis, particularly when customers operate under strict internal impurity specifications.
Lower-quality commercial materials may require additional purification before use, increasing processing time, material loss and production cost.
The industrial-grade CPA supplied by Liansheng is manufactured with controlled purity, water content and free amine residue for industrial synthesis applications.
Customers with specific pharmaceutical impurity requirements are encouraged to provide their target specifications for technical evaluation before commercial use.

 

2. Triazole Agrochemical Manufacturing
Cyclopropylacetylene is used as an upstream building block in selected agrochemical synthesis routes, including applications involving:
• Cyproconazole
• Pyrimidine fungicide intermediates
• Prothioconazole-related synthesis
• Other specialty fungicide intermediates
The cyclopropyl structure can be incorporated into downstream active-molecule synthesis.
Application Considerations
Consistent raw material quality is important for industrial agrochemical manufacturing, particularly where downstream synthesis and product registration require controlled impurity profiles.
Batch-to-batch variation in water, amine residues or other impurities may affect downstream processing.
The controlled industrial-grade specification is intended to support stable production and export-oriented agrochemical manufacturing.

 

3. Advanced Polymer & Specialty Material Synthesis
Cyclopropylacetylene can also be used in selected advanced material applications, including:
• UV-curable resin systems
• Modified acrylic resins
• Polyimide-related materials
• Specialty industrial coatings
• High-performance adhesives
• High-temperature engineering plastics
The alkyne functionality can participate in crosslinking and modification chemistry, while the cyclopropyl structure provides a specific structural element for specialty material design.
Potential applications include materials requiring improved temperature resistance, hydrolysis resistance and outdoor aging performance.
Actual suitability depends on the customer's formulation and synthesis process and should be validated through laboratory or pilot-scale testing.

 

4. Electronic Materials - Laboratory Evaluation
Small quantities of Cyclopropylacetylene may be used for laboratory research involving lithium battery materials, PCB-related materials and other electronic-material development projects.
This application is currently limited to R&D and small-scale evaluation.
The industrial-grade product is not positioned as an electronic-grade material for semiconductor, display or other large-scale electronic manufacturing processes.

 

Quality & Export Documentation

 

Documentation for International Customers
Standard export documentation can be provided with commercial shipments, including:
• Chinese and English GHS-compliant SDS/MSDS
• Batch-specific COA
• Complete analytical data and test records
• Certificate of Origin
• Manufacturer qualification documents
The production facility maintains the required environmental assessment, production safety and hazardous chemical production qualifications.
Overseas customers can arrange supplier qualification and on-site factory audits according to their internal EHS and procurement procedures.

 

Production & Supply Capability

 

Integrated Production
Unlike trading companies that purchase intermediates from external manufacturers and repackage the material, Liansheng operates as a source manufacturer.
Cyclopropylacetylene production is supported by the company's own Cyclopropanone production line, providing an integrated upstream supply structure.
This helps reduce dependence on external intermediate suppliers and provides greater control over production consistency.


Supply Advantages
 Integrated Raw Material Supply
Key upstream materials are supplied through the company's own production facilities, reducing exposure to external raw material shortages and short-term price fluctuations.
 Controlled Storage
The production site maintains low-temperature, explosion-proof storage tanks for inventory management.
Controlled storage helps minimize volatility and moisture-related changes during storage.
 Automated Production
The production line uses DCS-controlled automated synthesis and distillation.
Key quality parameters are monitored throughout production to maintain consistent purity and impurity levels between batches.
 Export Capability
The company has established procedures for international hazardous chemical shipments.
For standard export orders, hazardous chemical declaration, customs procedures and loading can generally be completed within 7–10 days, subject to order quantity, documentation and shipping schedules.

 

Packaging

 

Cyclopropylacetylene is volatile and sensitive to storage conditions. Export packaging is therefore designed to minimize exposure to light, moisture and air.
 R&D Samples
• 20 kg light-protected HDPE plastic drums
• Fully sealed packaging
• Moisture- and leak-resistant design
 Standard Export Orders
• 210 L heavy-duty corrosion-resistant light-protected drums
• Net weight: 150 kg per drum
• Sealed gasket system for leak protection
 Large-Volume Orders
• 1,000 kg sealed IBC containers
• Insulated ISO tank containers available for suitable bulk orders
Packaging specifications can be reviewed according to the customer's storage, transportation and handling requirements.

 

International Logistics & Storage

 

Transportation Protection
Export packaging is designed specifically for a volatile liquid and uses sealed, light-protective and corrosion-resistant construction.
Under normal ocean transportation conditions of approximately 45 days, the packaging is designed to minimize leakage and significant changes in product purity, water content and color when properly handled.


Hazardous Chemical Shipping
A dedicated export team supports hazardous chemical declaration, customs documentation and shipping procedures.
International transportation options can include:
• Full-container-load ocean freight
• LCL ocean freight
• Air freight for samples
• Other transportation solutions according to destination and regulatory requirements


Storage
Store in a cool, dry and explosion-proof environment with containers tightly sealed.
Temperature and humidity should be controlled to minimize evaporation and moisture-related changes.

 

Grade & Application Guidance

 

Application

Current Supply Status

Pharmaceutical Intermediate Synthesis

Industrial Grade ≥99.5%

Agrochemical Manufacturing

Industrial Grade ≥99.5%

Advanced Materials

Industrial Grade ≥99.5%, subject to process validation

Electronic Materials R&D

Small-scale samples only

Electronic Grade

Not available for mass production

Pharmaceutical Grade

Not available for mass production

The current commercial product is industrial grade only.
For customers requiring ultra-high-purity material, limited customized samples may be available for laboratory evaluation. Long-term bulk supply of electronic-grade or pharmaceutical-grade material is not currently available.

 

Purchasing Information

 

For quotation and technical evaluation, overseas buyers are recommended to provide:
• Required purity
• Application
• Estimated order quantity
• Packaging requirements
• Destination country
• Required quality documentation
• Specific impurity limits, if applicable
• Estimated annual demand
For pharmaceutical and agrochemical projects with defined internal specifications, customers are encouraged to provide their target analytical requirements before commercial qualification.

 

FAQ

 

Do you supply pharmaceutical-grade or electronic-grade Cyclopropylacetylene?

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The current commercial product is industrial grade with a purity of ≥99.5%.

There is currently no mass-production line for pharmaceutical-grade or electronic-grade Cyclopropylacetylene.

For customers requiring ultra-high-purity material, small customized samples may be available for laboratory evaluation. Long-term bulk supply of these grades is not currently available.

What is the advantage of buying directly from Liansheng?

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-

Liansheng is a source manufacturer rather than a trading company that purchases and repackages material from external suppliers.

Cyclopropylacetylene production is supported by the company's own Cyclopropanone production line, providing greater control over upstream raw materials, synthesis, distillation and final product quality.

This integrated production structure helps reduce batch-to-batch variation and dependence on external intermediate suppliers.

How is batch consistency controlled?

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-

The production line uses DCS-controlled automated synthesis and distillation.

Purity, water content, free amine residue and other key quality parameters are controlled during production.

Each commercial batch can be supplied with a batch-specific COA and corresponding analytical data.

Can you provide third-party testing?

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-

Yes.

Customers can arrange independent testing through qualified third-party laboratories according to their supplier qualification procedures.

Relevant batch samples and product documentation can be provided to support the testing process.

Will Cyclopropylacetylene evaporate or deteriorate during long-distance ocean transportation?

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-

Cyclopropylacetylene is a volatile liquid and should remain tightly sealed during storage and transportation.

Export packaging uses sealed, light-protective and corrosion-resistant structures designed to minimize evaporation and exposure to moisture and air.

Under normal ocean transportation conditions of approximately 45 days, the packaging is designed to help maintain product purity, water content and color when properly handled.

What storage conditions are recommended?

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-

Store in a cool, dry and explosion-proof environment.

Keep containers tightly closed and minimize exposure to heat, air and moisture.

Appropriate temperature and humidity control should be maintained throughout storage.

What packaging options are available?

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-

Current packaging options include:

• 20 kg HDPE drums for R&D samples

• 150 kg net-weight drums for standard export orders

• 1,000 kg IBC containers for bulk orders

• Insulated ISO tank containers for suitable large-volume shipments

What is the typical export lead time?

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-

For standard export orders, hazardous chemical declaration, customs procedures and loading can generally be completed within 7–10 days, subject to order quantity, documentation and shipping schedules.

Can you support long-term supply agreements?

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-

Yes.

Qualified customers can discuss 1–3-year annual framework agreements, including price-lock and supply arrangements based on forecast demand and agreed commercial terms.

The integrated upstream supply structure is intended to support stable availability during periods of higher demand.

Can I order a small quantity for R&D testing?

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-

Yes.

R&D samples are available from small quantities, subject to product availability and shipping requirements.

Customers should provide the intended application, required specification and destination country when requesting a sample or quotation.

 

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