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- Chinese alias: Diethyl oxalate

Diethyl Oxalate (DEO) is a reactive diester building block used primarily in pharmaceutical and agrochemical synthesis, as well as selected polymer and coating applications.
Liansheng operates a dedicated 8,000-ton-per-year continuous synthesis and distillation line for Diethyl Oxalate. The product is commercially available in two purity grades:
• 99.5% - Standard Industrial Grade
• 99.9% - High-Purity Pharmaceutical Grade
The production process combines solid-acid esterification with multi-stage vacuum distillation to control residual ethanol, free oxalic acid and other key impurities.
Electronic-grade and injectable pharmaceutical-grade Diethyl Oxalate are not currently produced on a mass-production basis. For wafer-cleaning or other ultra-high-purity laboratory applications, small quantities of customized samples can be provided for evaluation, but long-term bulk supply is not currently available.
Key Product Information
|
Item |
Specification |
|
Product Name |
Diethyl Oxalate |
|
Abbreviation |
DEO |
|
CAS No. |
95-92-1 |
|
Molecular Formula |
C₆H₁₀O₄ |
|
Appearance |
Colorless, clear oily liquid |
|
Odor |
Mild ester-like odor |
|
Available Purity |
99.5% / 99.9% |
|
Standard Grade |
Industrial / Pharmaceutical Grade |
|
Commercial Availability |
99.5% and 99.9% bulk production |
|
Electronic Grade |
Not available for mass production |
|
Injectable Pharmaceutical Grade |
Not available for mass production |
Diethyl oxalate is used as a reactive diester building block in condensation and transesterification reactions, with applications across pharmaceutical, agrochemical and specialty chemical manufacturing.
Technical Specifications
Each commercial batch is supplied with a batch-specific COA and complete GC test results.
Standard Industrial Grade
|
Test Item |
Specification |
|
Assay Purity |
≥99.50% |
|
Water Content |
≤250 ppm |
|
Color |
≤15 APHA |
|
Density at 20°C |
1.077–1.082 g/cm³ |
|
Boiling Point at Atmospheric Pressure |
185.4°C |
The production process uses continuous synthesis and multi-stage distillation to maintain consistent batch specifications and control key impurities.
For customers requiring the 99.9% high-purity pharmaceutical grade, the applicable specification and documentation can be confirmed according to the intended application before order confirmation.
Diethyl oxalate Uses
Introduction
Diethyl oxalate appears as a colorless oily liquid with an aromatic scent; in terms of solubility, it is miscible in most organic solvents such as ethanol, ether, and ethyl acetate; density: relative density (water=1) 1.08; relative density (air=1) 5.04; stability: stable. It is primarily used as a solvent, dye intermediate, and in the synthesis of paints and pharmaceuticals.

Applications
1. Pharmaceutical API & Fine Chemical Manufacturing
Diethyl Oxalate is used as a synthetic building block in the industrial production of pharmaceutical intermediates and active pharmaceutical ingredients, including applications involving:
• Phenobarbital
• Azathioprine
• Anti-Parkinson's pharmaceutical intermediates
Its diester structure can participate in condensation and cyclization reactions and can be incorporated into multi-step synthesis routes.
For Pharmaceutical Manufacturers
Residual alcohol, free acid and other impurities in raw materials can affect downstream reaction performance and the impurity profile of pharmaceutical intermediates or APIs.
The production process is designed to control key impurities through esterification and multi-stage vacuum distillation.
The 99.9% high-purity grade is available for pharmaceutical applications where tighter raw material specifications are required.
Customers with specific impurity limits or pharmaceutical quality requirements can submit their target specifications for technical review before commercial use.

2. Agrochemical Manufacturing
Diethyl Oxalate is used as an upstream synthetic building block in agrochemical manufacturing, including applications involving:
• Triazole fungicides
• Selective herbicides
• Other agrochemical intermediates
It participates in downstream synthesis for constructing active molecular structures and is suitable for processes where consistent raw material quality is required.
For Agrochemical Manufacturers
Batch-to-batch variation in raw material purity or impurity levels can affect downstream synthesis and product consistency.
Controlled synthesis and continuous distillation provide consistent product specifications for customers conducting industrial agrochemical production.
3. Polymers & Coatings
Diethyl Oxalate can also be used in selected polymer and specialty coating applications.
Potential applications include:
• Polyimide-related synthesis
• Biodegradable polyester production
• Specialty synthetic resins
• Industrial coating systems
• Corrosion-resistant resin formulations
In specialty resin systems, Diethyl Oxalate can serve as a reactive raw material or synthesis component where controlled chemical properties are required.
Application Considerations
For overseas manufacturers, raw material selection may need to consider both process performance and market-specific regulatory requirements.
Diethyl Oxalate is positioned for industrial applications where controlled specifications and supply consistency are important.
Quality & Regulatory Documentation
U.S. TSCA Status
Diethyl Oxalate is listed on the existing U.S. TSCA chemical substance inventory. Based on this inventory status, an additional PMN submission is not required for the substance.
Relevant regulatory documentation can be provided for customer import and compliance review.
Production Site & EHS Support
The Linhai production facility maintains the required environmental assessment, production safety and pollutant discharge documentation.
The facility is certified to:
• ISO 9001
• ISO 14001
• ISO 45001
The production site can support EHS and GMP-related supplier audits by overseas pharmaceutical and agrochemical customers according to project requirements.
Documentation Available
Each commercial shipment can be supplied with:
• Chinese and English GHS-compliant SDS/MSDS
• Batch-specific COA
• Original GC test chromatograms
• Manufacturer qualification documents
• Certificate of Origin
• SGS or Intertek third-party impurity testing reports upon request
These documents can support supplier qualification, import review, quality control and customer audit procedures.
Production & Supply Capability
Dedicated Production Capacity
Liansheng operates a dedicated 8,000-ton-per-year Diethyl Oxalate continuous synthesis and distillation line.
The production system operates independently and can be switched to supporting co-production of ethylene carbonate and other products according to production planning.
Upstream esterification raw materials are sourced through nearby supporting facilities, reducing dependence on externally purchased crude ester intermediates.
Inventory
The production site uses dedicated temperature-controlled and corrosion-resistant storage tanks with separate storage areas.
Safety stock is maintained for regular customer orders.
Available supply formats include:
• 25 kg R&D samples
• 200 kg orders
• 1,000 kg IBC containers
• Full-container shipments
Supply Agreements
For qualified overseas customers, Liansheng can consider:
• 1–3-year annual framework agreements
• Annual price-lock arrangements
• Delivery commitment agreements
• Credit-term qualification for eligible customers
Long-term customers can also discuss production scheduling arrangements based on forecast demand.
Lead Time
Domestic stock: Generally available for dispatch within 3 days.
Export orders: Hazardous chemical declaration and customs clearance can generally be completed within 7–10 days, subject to order quantity, documentation and shipping schedules.
Shipments can be arranged from Chinese ports to major pharmaceutical and agrochemical markets in Europe, North America, Southeast Asia, Japan, South Korea and other international destinations, subject to applicable import and transportation requirements.
Packaging
Diethyl Oxalate can undergo gradual hydrolysis when exposed to water. Export packaging is therefore designed to minimize moisture ingress during storage and transportation.
R&D Samples
• 25 kg plastic drums
• Double-layer PE inner liner
• Light-protected and fully sealed packaging
• Moisture-resistant design
Standard Export Orders
• 210 kg heavy-duty corrosion-resistant plastic drums
• Net weight: 180 kg per drum
• Double-layer hydrolysis-resistant sealing gaskets
Large-Volume Orders
• 1,000 kg sealed IBC containers
• Insulated ISO tank containers available for suitable bulk orders
Packaging specifications can be reviewed according to destination-country requirements and transportation conditions.
International Logistics
Moisture Protection
Export packaging uses a sealed, light-protective and moisture-resistant structure designed to minimize exposure to air and water during transportation.
Under normal ocean transportation conditions of approximately 45 days, the packaging is designed to minimize moisture absorption and hydrolysis and help maintain the specified water content, residual ethanol and assay purity when properly handled.
Hazardous Chemical Shipping Support
A dedicated international trade team supports applicable hazardous chemical declarations, maritime filing and export documentation.
Transportation Options
• Full-container-load ocean freight
• LCL ocean freight
• Air freight for samples
Chemical cargo insurance can be arranged for international shipments according to customer requirements.
Storage Conditions
Store in a dry, sealed warehouse under normal temperature conditions.
Keep away from water sources and strongly alkaline materials.
The product should be protected from conditions that may promote hydrolysis during storage.
Grade Selection
|
Application |
Recommended Grade |
|
General Industrial Synthesis |
99.5% Standard Grade |
|
Agrochemical Manufacturing |
99.5% / 99.9% according to process requirements |
|
Pharmaceutical Synthesis |
99.9% High-Purity Grade where required |
|
Fine Chemical Manufacturing |
99.5% / 99.9% according to process requirements |
|
Laboratory Evaluation |
Customized high-purity samples available |
|
Semiconductor / Wafer Applications |
No mass-produced electronic grade |
|
Injectable Pharmaceutical Applications |
No mass-produced injectable grade |
For pharmaceutical or other regulated applications, customers should provide their required impurity profile and quality specifications before order confirmation.
Purchasing Information
For quotation and technical evaluation, overseas buyers are recommended to provide:
• Required purity: 99.5% or 99.9%
• Application
• Estimated order quantity
• Packaging requirement
• Destination country
• Required quality documents
• Specific impurity limits, if applicable
• Estimated annual demand for long-term supply
This information allows the supply team to confirm the appropriate grade, packaging, documentation and delivery arrangement.
FAQ
What purity grades of Diethyl Oxalate are available?
+
-
Two commercial grades are available:
• 99.5% Standard Industrial Grade
• 99.9% High-Purity Pharmaceutical Grade
Electronic-grade and injectable pharmaceutical-grade products are not currently available from a dedicated mass-production line.
Can you supply electronic-grade Diethyl Oxalate in bulk?
+
-
No. There is currently no dedicated mass-production line for electronic-grade Diethyl Oxalate.
For semiconductor, wafer-cleaning or other ultra-high-purity laboratory applications, limited quantities of customized high-purity samples can be provided for evaluation. Long-term bulk supply is not currently available.
Can you supply injectable pharmaceutical-grade Diethyl Oxalate?
+
-
The current commercial product range includes 99.5% standard industrial grade and 99.9% high-purity pharmaceutical grade. There is no dedicated mass-production line for injectable pharmaceutical-grade Diethyl Oxalate.
For pharmaceutical applications, customers should provide their specific quality and impurity requirements for evaluation.
What is the difference between the 99.5% and 99.9% grades?
+
-
The primary difference is the specified purity level and the corresponding application requirements.
The 99.5% grade is intended for general industrial synthesis and applications where the standard specification is sufficient.
The 99.9% grade is intended for applications requiring tighter raw material purity control, including selected pharmaceutical synthesis.
Is Diethyl Oxalate sensitive to moisture during transportation?
+
-
Yes. Diethyl Oxalate can undergo gradual hydrolysis when exposed to water.
For export shipments, sealed double-layer PE-lined packaging is used to minimize exposure to moisture and air. Under normal ocean transportation conditions of approximately 45 days, the packaging is designed to help maintain the specified water content, residual ethanol and assay purity when properly handled.
Can moisture during ocean transportation affect the product quality?
+
-
The export packaging is designed to minimize moisture ingress during long-distance transportation.
For specific projects with strict water-content requirements, customers can request additional packaging or specification requirements for technical review before shipment.
What quality documents are provided with each batch?
+
-
Each commercial shipment can be supplied with:
• Batch-specific COA
• Complete GC test results and original chromatograms
• Chinese and English GHS-compliant SDS/MSDS
• Manufacturer qualification documents
• Certificate of Origin
SGS or Intertek third-party impurity testing reports can also be provided upon request.
Can you support EHS or GMP supplier audits?
+
-
Yes. The production facility maintains ISO 9001, ISO 14001 and ISO 45001 certifications and can support EHS and GMP-related supplier audits according to customer requirements.
Can you support long-term supply contracts?
+
-
Yes. Qualified customers can discuss 1–3-year annual framework agreements, including price-lock and delivery arrangements based on forecast demand and agreed commercial terms.
What packaging options are available?
+
-
Standard options include 25 kg plastic drums for R&D samples, 210 kg heavy-duty plastic drums for regular export shipments, and 1,000 kg sealed IBC containers for bulk orders.
Insulated ISO tank containers can be considered for suitable large-volume orders.
What is the typical export lead time?
+
-
For export orders, hazardous chemical declaration and customs clearance can generally be completed within 7–10 days, subject to order quantity, documentation and shipping schedules.
Domestic stock can generally be dispatched within 3 days.
What information is required for a quotation?/p>
+
-
Please provide the required purity, application, order quantity, destination country, packaging requirements, required documentation and any specific impurity limits.
For long-term supply projects, an estimated annual demand is also recommended.
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